Streptozocin-Diabetes Modifies Acetylcholine Release from Mouse Phrenic Nerve Terminal and Presynaptic Sensitivity to Succinylcholine
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منابع مشابه
Nerve terminal currents induced by autoreception of acetylcholine release.
The activation of autoreceptors is known to be important in the modulation of presynaptic transmitter secretion in peripheral and central neurons. Using whole-cell recordings made from the free growth cone of myocyte-contact motoneurons of Xenopus cell cultures, we have observed spontaneous nerve terminal currents (NTCs). These spontaneous NTCs are blocked by d-tubocurarine (d-TC) and alpha-bun...
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Whole-mount stereo electron microscopy has been used to examine the cytoskeletal organization of the presynaptic nerve terminal and the acetylcholine receptor (AChR) clusters in cultures of Xenopus nerve and muscle cells. The cells were grown on Formvar-coated gold electron microscope (EM) finder grids. AChR clusters were identified in live cultures by fluorescence microscopy after labeling wit...
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Release of chemical messengers from synaptic vesicles is the result of a highly orchestrated process of membrane trafficking in the presynaptic nerve terminal. Understanding the molecular mechanisms that govern synaptic vesicle membrane trafficking is of inherent interest to cell biologists; however, an additional fascination arises from the notion that the modulation of neurotransmitter releas...
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Potassium concentrations above 15-20 mM in the medium, or addition of 75 muM veratridine to medium that contains 5 mM K, stimulate calcium accumulation and Ca-dependent norepinephrine release by presynaptic nerve terminals (synaptosomes) incubated in vitro. The effects of veratridine, but not of K, are blocked by 0.2 muM tetrodotoxin. This association between Ca entry and norepinephrine release...
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ژورنال
عنوان ژورنال: Japanese Journal of Pharmacology
سال: 1993
ISSN: 0021-5198
DOI: 10.1254/jjp.62.245